Overview

At CD ComputaBio, we offer industry-leading pharmacokinetic simulation services. Based on the fundamental principles of biology, chemistry, and pharmacology, we provide accurate, efficient, and comprehensive simulation services that help researchers gain insight into the pharmacokinetics of various drugs and biologically active substances.

Figure 1. Pharmacokinetics absorption, distribution, metabolism, and excretion. (Alghamdi M A, et al.)

Our Services

At CD ComputaBio, we offer a variety of pharmacokinetic modeling services based on the specific needs of our clients:

• Pharmacokinetic Modeling

Our team of experts specializes in developing and applying pharmacokinetic models to predict the absorption, distribution, metabolism, and excretion (ADME) of drugs. We utilize physiologically based pharmacokinetic (PBPK) models and compartmental models to simulate the behavior of drugs in different tissues and different species.

• Dosage Optimization

By combining pharmacokinetic simulations with dose-response modeling, we assist our clients in optimizing drug dosage regimens to achieve desired therapeutic effects while minimizing the risk of adverse effects.

• Drug Interaction Prediction

We use advanced algorithms to predict potential drug interactions, including evaluating metabolic interactions, transporter interactions, and pharmacodynamic interactions.

• Formulation Design

We support the formulation development process with computational simulations of drug release, absorption, and distribution to optimize formulation properties and bioavailability.

Applications

Pharmacokinetic Simulation plays a pivotal role in accelerating drug discovery, development, and optimization processes. The detailed understanding of drug interactions, metabolism, distribution, and elimination provided through our services aids in:

• Optimizing drug dosage forms and schedules
• Understanding drug interactions and possible side effects
• Predicting drug disposition in patients
• Personalizing drug therapy and ushering in precision medicine
• Estimating the behavior of newly discovered molecules in humans
• Determining treatment effectiveness in heterogeneous populations

Algorithms

Our pharmacokinetic simulation services are based on a suite of advanced algorithms and computational methods:

• Monte Carlo Simulation: Monte Carlo methods are used to probabilistically simulate drug behavior, taking into account the variability of physiological parameters, drug properties, and dosing regimens.
• Machine Learning and Data Integration: Our algorithms utilize machine learning techniques and data integration to predict drug metabolism, drug transport, and drug-drug interactions based on large datasets of pharmacokinetic and pharmacodynamic information.

Sample Requirements

We require the following key information to conduct our pharmacokinetic simulation services:

• Therapeutic indications for the drug
• Pre-clinical and clinical data
• Dose-response relationships
• Pharmacokinetic parameters
• Possible drug-drug interactions
• Pathophysiological information of target populations

Why Choose Us?

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